Canine Microbiome
Introduction to the canine: The canine microbiome is quickly becoming a focus by researchers to identify and manage chronic diseases. This short video is an overview of the basics of understanding the microbiome and its role within our canine companions.
Read the full write-up here.
Diverse Microbiome
Ecology 101 states that biodiversity is a predictor of health for most ecosystems. The human and mammalian microbiome is no exception. While there are many controversies and confounding variables left to interpretation from research on the microbiome, meta-analysis and review studies indicate that a diverse microbiome is a consistent predictor of health within a species and that a lack of microbial diversity (LOMD) is indicative of dysbiosis and correlate with an epidemic of chronic Western disease.
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Antimicrobial Stewardship
It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.
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Hygiene Hypothesis
It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.
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Canine Skin Microbiome
It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.
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DC Shiba Inu Rescue ‘Allergy Program’
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Fecal Microbiota Transplant
Animal Biome, FMT,
2018 study shows that researchers find the canine microbiome is more similar to the human microbiome than originally thought.
Findings:
⭐️Researchers at the European Molecular Biology Laboratory and Nestle Research found that the gene content of the dog's microbiome was more similar to humans than the microbiome of pigs and mice. Implications are more studies done on dogs as a precursor to human studies.
⭐️The microbiomes of overweight and obese dogs were found to be more responsive to a high protein diet compared to the microbiomes of lean dogs.
⭐️The study was a randomized controlled trial with 32 beagles and 32 retrievers with an equal number of lean and overweight dogs. All dogs were fed the same base diet of commercially available dog food for four weeks and then were randomized into two groups; 1. high protein with low card or 2. High carb with a low protein diet for four weeks. Researchers then compared DNA extraction to create a microbiome gene catalog. The dog gene catalog was compared to existing gene catalogs from humans, mice, and pigs to assess the similarities in gene content and response to diet change. Results indicate that the canine microbiome has more similarities than the mice or pigs which are commonly used as a precursor to human studies.
⭐️Researchers caution that while dogs and humans host similar microbes, they are not the same microbes but related strains of the same species. (Implications: More canines used in laboratories to study the impact of diet on the human microbiome. The basis to extrapolate data from human studies to canine studies and vice versa) Original Source: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0450-3
Scientists are learning why some people get sick from salmonella and others are not affected. There is more support for the terrain of the microbiome over simple exposure of a pathogen, A recent study published in the journal Cell Host & Microbe, Stanford University School of Medicine researchers found that a short-chain fatty acid produced by bacteria, called propionate can help protect against Salmonella infections. Specifically, propionate interferes with the ability of Salmonella to divide and grow by increasing the internal acidity.
#diversemicrobiome #SCFA #proprionate #ecologyofmicrobiome #terrain
"Jacobson et al. show that the composition of the host microbiota controls intestinal expansion of the enteric pathogen S. Typhimurium. They demonstrate that Bacteroides spp. mediate colonization resistance to S. Typhimurium infection through production of the short-chain fatty acid propionate, which directly limits pathogen growth by disrupting intracellular pH homeostasis."
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30371-8
The importance of the gut microbiota in the success of a ketogenic diet (with seizure). Our program always primes the gut prior to undertaking a ketogenic diet. While we do not have the exact blueprint for the balance of microbes, a diverse microbiome is a default to ensure a high-functioning microbiota.
Key points:
Two strains of bacteria increased on Keto Diet
1. Akkermansia muciniphila
2. Parabacteroides Both promote seizure protection in response to the KD in germ-free mice.
This, in turn, changed levels o an enzyme called, gamma-glutamyltranspeptidase (GGT) which changed the ratio of GABA and glutamate in the brain and delayed the onset of the seizure in the predisposed animal.
"The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet"
"The microbiota plays a key role in host digestion, metabolism, and behavior, but whether microbial responses to diet also impact neuronal activity is poorly understood. Here, we demonstrate that the KD alters the gut microbiota across two seizure mouse models, and changes in the microbiota are necessary and sufficient for conferring seizure protection. Several clinical studies link antibiotic treatment to increased risk of status epilepticus or symptomatic seizures in epileptic individuals."
Link to study: https://linkinghub.elsevier.com/retrieve/pii/S0092867418305208